Paper scaffolds

Real-time imaging of cancer cell chemotaxis in paper-based scaffolds.

Cellular migration is the movement of cells, cultured as a monolayer; cellular invasion is similar to migration, but requires the cells to move through a three-dimensional material such as basement membrane extract or a synthetic hydrogel. Migration assays, such as the transwell assay, are widely used to study cellular movement because they are amenable to high-throughput screens with minimal e...

Bioresorbable scaffolds: everything resolved?

So, knowing the good results with DES the question is if there is still room and need for further improvement? After the introduction of the bioresorbable scaffold (BRS) and the promising results of the Absorb A and B trial, one would think that we are really missing the boat if we do not use this novel but still expensive device. The major advantage of the new scaffolds promises to overcome th...

ERK Signals: Scaffolding Scaffolds?

ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of the module into a multi-enzymatic complex by which signal amplitude and duration are fine-tuned, and also provide signal fidelity by isolating...

FRET-ing over scaffolds

pposites really do attract. Results on page 101 by Oliveria et al. show that, although they perform opposing functions, a kinase and a phosphatase linked to synaptic plasticity are close neighbors at the plasma membrane. The two are brought together by the scaffolding protein AKAP79 into a complex that may be important for efficient learning. The close proximity of the three proteins is uncover...

Biofabrication of Tissue Scaffolds